岡山大学 学術研究院医歯薬学域(薬学系)
臨床基礎統合薬学分野 ホームページ
研究業績
2025年度
英文
原著論文
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邦文
総説
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早川兼司,小林豊,近藤悠希,磯野哲一郎,井上彰夫,津下遥香,藤山信弘,増田展利,森住誠,矢羽羽雅行,山本和宏,山本武人,浦田元樹:CKD シールの現状と課題.日本腎臓病薬物療法学会誌,14(2): 171-184, 2025
原著論文
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辻屋徳恵,山本和宏,木村丈司,丸川千佳,飯田真之,谷藤亜希子,野崎晃,宇田篤史,山下和彦,大本暢子,大村友博,矢野育子:調剤自動化システムおよびピッキングサポートシステム導入による調剤過誤および疑義照会への影響
医療薬学,印刷中 -
大東真理子,浦嶋和也,山本和宏,林八恵子,浦田元樹,西口工司,辻本雅之:認定資格の有無による腎移植に対する意識・知識の比較~服薬指導時の固定観念回避のために~.日本腎臓病薬物療法学会誌,14(2):185-196, 2025
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堀智貴,山本和宏,中逵穂,牧浦耕平,吉岡奈津恵,青木勝也,生島繁樹:ペムブロリズマブ+レンバチニブ療法開始後にサイトカイン放出症候群が疑われる症例に対するステロイド早期治療により重篤化を回避した1例.日本病院薬剤師会雑誌,61(8):836-841, 2025
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津田瑞季,丹田雅明,大村友博,伊藤雄大,飯田真之,丸上奈穂,山口由加里,大本暢子,山本和宏,矢野育子:外来がん薬物療法における病院と保険薬局の連携強化によるトレーシングレポートを介した薬学的介入の変化とその効果.医療薬学,51(4): 203-212, 2025
受賞
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医療薬学フォーラム2025 第33回クリニカルファーマシーシンポジウム 優秀ポスター賞
玉村麻有,橋本真梨,山本和宏,藤原尚子,今福仁美,北廣優実,大村友博,篠原正和,上田昌史,矢野育子
後発リトドリン注射製剤による痒疹発現と原因化合物の探索
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第18回 臨床薬理研究振興財団 研究大賞
新生児におけるフェンタニルの有害反応と薬物動態の評価:生理学的薬物動態モデリング&シミュレーションによるアプローチ
2024年度
英文
原著論文
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Kariya M, Yamamoto K, Kawamura A, Tanizaki S, Ueda K, Sai K, Hata A. Cystine and theanine for chemoradiotherapy-induced esophagitis in non-small cell lung cancer: a prospective observational study. Support Care Cancer, 32:400 (2024)
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Sakaue T, Yamamoto K, Itohara K, Kitahiro Y, Endo T, Yokoyama N, Ishimura T, Omura T, Yano I. Population pharmacokinetics of everolimus in renal transplant recipients receiving long-term multiple immunosuppressive therapy. Drug Metab Pharmacokinet, In press
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Hori T, Yamamoto K, Ito T, Ikushima S, Omura T, Yano I. Effect of early dose reduction of osimertinib on efficacy in the first-line treatment for EGFR-mutated non-small cell lung cancer. Invest New Drugs, In press
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Konishi T, Kitahiro Y, Fujiwara N, Yamamoto K, Hashimoto M, Ito T, Itohara K, Fujioka K, Imafuku H, Otsuka I, Omura T, Yano I. Pharmacokinetics of Brexpiprazole, Quetiapine, Risperidone and Its Active Metabolite Paliperidone in a Postpartum Woman and Her Baby: A Short Communication. Ther Drug Monit, In press
邦文
総説
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山本和宏:血中濃度の変動要因を見極めよう 悩ましい薬物動態の諸問題「腎機能低下」.月刊薬事,66(3):71-74, 2024
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山本和宏:「がん薬物療法時の腎障害診療ガイドライン2022」について.日本薬剤師会雑誌,76(2):13-19, 2024
原著論文
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荻原孝史,山本和宏,村川亜光,髙木妙子,阪上倫行,木村丈司,藤田浩平,宇田篤史,大村友博,矢野育子:薬剤師によるバンコマイシン血中濃度測定オーダー登録と注射薬処方オーダー仮登録がもたらす実践的有用性の評価
TDM研究,41(4):117-124, 2024 -
冨田猛,山本和宏,木村丈司,宇田篤史,土生康司,大本暢子,山下和彦,大村友博,矢野育子:院外処方における臨床検査値を用いた2段階チェック機能の有用性:処方禁忌警告システムと処方せんへの検査値印字.医療薬学,50(6):277-286, 2024
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志田有里,飯田真之,番匠咲帆,蓼原瞬,大本暢子,山本和宏,大村友博,丹生健一,矢野育子:オピオイド鎮痛薬を入院中に開始した外来頭頸部がん患者を対象とした病院薬剤師による電話サポート介入の効果.日本緩和医療薬学雑誌,17(3): 87-94, 2024
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岡崎裕太朗,大村友博,上田昌史,武田紀彦,竹下治範,飯田真之,山下和彦,木村丈司,大本暢子,山本和宏,土生康司,宮田興子,矢野育子:テルミサルタン錠の変色原因は添加剤のメグルミンによるドパミン誘導体の分解物である.日本病院薬剤師会雑誌,60(4):395-401, 2024
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古江由依,山本和宏,木村丈司,高橋知子,川瀬愛子,清水倫子,飯田真之,松本久美子,大本暢子,山下和彦,大村友博,坂根稔康,國正淳一,矢野育子:潜在的不適切処方の中止維持における退院時薬剤情報提供の効果.医療薬学,50(2):75-83, 2024
受賞
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2024年日本臨床薬理学会 学術奨励賞
腎機能障害患者におけるがん薬物療法の新規用量設計法の確立に向けた生理学的薬物動態モデル&シミュレーションとビッグデータの統合解析
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2024 年度日本医療薬学会 JPHCS誌論文賞
Kurimura T*, Yamamoto K*, Tanaka H, Toba T, Kimura T, Habu Y, Itohara K, Kitahiro Y, Omura T, Yano I
*The two authors contributed equally to this work.
Significance of pharmacist intervention to oral antithrombic therapy in the pharmaceutical outpatient clinic of cardiovascular internal medicine: A retrospective cohort study. J Pharm Health Care Sci, 9(1):28, 2023
2023年度
英文
総説
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Yanagita M, Muto S, Nishiyama H, Ando Y, Hirata S, Doi K, Fujiwara Y, Hanafusa N, Hatta T, Hoshino J, Ichioka S, Inoue T, Ishikura K, Kato T, Kitamura H, Kobayashi Y, Koizumi Y, Kondoh C, Matsubara T, Matsubara K, Matsumoto K, Okuda Y, Okumura Y, Sakaida E, Shibagaki Y, Shimodaira H, Takano N, Uchida A, Yakushijin K, Yamamoto T, Yamamoto K, Yasuda Y, Oya M, Okada H, Nangaku M, Kashihara N. Clinical questions and good practice statements of clinical practice guidelines for management of kidney injury during anticancer drug therapy 2022. Clin Exp Nephrol, 28(2):85-122 (2024)
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Muto S, Matsubara T, Inoue T, Kitamura H, Yamamoto K, Ishii T, Yazawa M, Yamamoto R, Okada N, Mori K, Yamada H, Kuwabara T, Yonezawa A, Fujimaru T, Kawano H, Yokoi H, Doi K, Hoshino J, Yanagita M. Chapter 1: Evaluation of kidney function in patients undergoing anticancer drug therapy, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022. Int J Clin Oncol, 28(10):1259-1297 (2023)
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Nishiyama H, Inoue T, Koizumi Y, Kobayashi Y, Kitamura H, Yamamoto K, Takeda T, Yamamoto T, Yamamoto R, Matsubara T, Hoshino J, Yanagita M; committee of Clinical practice guidelines for the management of kidney disease during anticancer drug therapy 2022. Chapter 2: indications and dosing of anticancer drug therapy in patients with impaired kidney function, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022. Int J Clin Oncol, 28(10):1298-1314 (2023)
原著論文
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Kitahiro Y, Yamamoto K, Yakushijin K, Ioroi T, Tanda M, Itohara K, Omura T, Minami H, Yano I. The Efficacy of Bepotastine Besilate Compared With Hydroxyzine Pamoate for Preventing Infusion Reactions to the First Dose of Rituximab in Patients With Non-Hodgkin Lymphoma: Protocol for a Phase II, Double-Blind, Multicenter Randomized Trial. JMIR Res Protoc, 13: e54882 (2024)
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Sakaue T, Yamamoto K, Itohara K, Kitahiro Y, Endo T, Yokoyama N, Ishimura T, Omura T, Yano I. Population pharmacokinetics of everolimus in renal transplant recipients receiving long-term multiple immunosuppressive therapy. Drug Metab Pharmacokinet. 56: 101009 (2024)
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Nishiguchi H, Omura T, Sato A, Kitahiro Y, Yamamoto K, Kunimasa J, Yano I. Luteolin protects against 6-hydoroxydopamine-induced cell death via an upregulation of HRD1 and SEL1L. Neurochem Res, 49 (1): 117-128 (2024)
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Tanda M, Yamamoto K, Hori T, Nishiguchi H, Yagi M, Shimizu M, Konishi T, Ozaki T, Yoshioka N, Tachihara M, Ito T, Ikushima S, Omura T, Yano I. Association of STAT3, CYP3A5, and ABCG2 Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients. Anticancer Res, 43 (4): 1775-1783 (2023)
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Mahdy WYB, Yamamoto K, Ito T, Fujiwara N, Fujioka K, Horai T, Otsuka I, Imafuku H, Omura T, Iijima K, Yano I. Physiologically-based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate. Clin Transl Sci, 16 (4): 618-630 (2023)
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Fujimoto T, Hyodo Y, Ishimura T, Tashiro Y, Endo T, Nisioka S, Yokoyama N, Yamamoto K, Yano I, Fujisawa M. Association of alpha-actinin-3 polymorphism with sarcopenia in kidney transplant recipients. Transplant Proc, 55 (4): 824-828 (2023)
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Hori T, Yamamoto K, Ito T, Ikushima S, Omura T, Yano I. Upfront Use of First-/Second-Generation EGFR-TKI Followed by Osimertinib Shows Better Prognosis than Upfront Osimertinib Therapy in Japanese Patients with Non-small-cell Lung Cancer with Exon 19 Deletion: A Single-Center Retrospective Study. Biol Pharm Bull, 46 (6): 788-795 (2023)
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Kurimura T, Yamamoto K, Tanaka H, Toba T, Kimura T, Habu Y, Itohara K, Kitahiro Y, Omura T, Yano I. Significance of pharmacist intervention to oral antithrombotic therapy in the pharmaceutical outpatient clinic of cardiovascular internal medicine: a retrospective cohort study. J Pharm Health Care Sci, 9 (1): 28 (2023)
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Nakayama Y, Enomoto D, Yamamoto K, Takara K. Molecular Characteristics of Everolimus-resistant Renal Cell Carcinoma Cells Generated by Continuous Exposure to Everolimus. Anticancer Res, 43 (10): 4349-4357 (2023)
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Tomida T, Itohara K, Yamamoto K, Kimura T, Fujita K, Uda A, Kitahiro Y, Yokoyama N, Hyodo Y, Omura T, Yano I. A model-based pharmacokinetic assessment of drug-drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19. Drug Metab Pharmacokinet, 53: 100529 (2023)
邦文
総説
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山本和宏.分子標的型抗がん薬による間質性肺疾患発症の分子機構に基づく予測法の開発 —mTOR阻害薬による間質性肺疾患とSTAT3の関連—.YAKUGAKU ZASSHI, 143(11): 911-916 (2023)
原著論文
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古江由依,山本和宏,木村丈司,高橋知子,川瀬愛子,清水倫子,飯田真之,松本久美子,大本暢子,山下和彦,大村友博,坂根稔康,國正淳一,矢野育子.潜在的不適切処方の中止維持における退院時薬剤情報提供の効果.医療薬学,50 (2): 75-83 (2024)
著書(分担執筆)
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山本和宏.14.血清補正Ca濃度の高い高リン血症のCKD患者に対して薬剤は、何を選ぶ?:100-105,39. CKD患者における緊急性の高い高カリウム血症に対して治療薬は,何を選ぶ?:261-265月刊薬事 2023年10月臨時増刊号(Vol. 65, No. 14),じほう(2023)
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山本和宏.透析医療をささえる人びと “たかが便秘、されど便秘”.腎不全を生きる.日本腎臓財団,68:6-19 (2023)
受賞
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第16回日本緩和医療薬学会学術大会 口頭発表最優秀演題賞
飯田真之,志田有里,番匠咲帆,大本暢子,山下和彦,槇本博雄,山本和宏,大村友博,矢野育子:非がん性疼痛に対して使用されるオピオイド性鎮痛薬の薬剤師による使用状況モニタリングとその効果 -
第6回フレッシャーズ・カンファランス 優秀演題発表賞
高橋大,山本和宏,西口大生,糸原光太郎,北廣優実,大村友博,國正淳一,矢野育子:肺胞上皮細胞におけるエベロリムスの上皮間葉転換誘導とシグナル伝達因子の関連 -
2023年度日本医療薬学会 JPHCS誌論文賞
木村丈司,藤田美佐,清水倫子,住吉霞美,番匠咲帆,山本和宏,大村友博,矢野育子:Effectiveness of pharmacist intervention for deprescribing potentially inappropriate medications: a prospective observational study," J Pharm Health Care Sci, 8 (1): 12 (2022) -
第33回日本医療薬学会年会 優秀演題賞(International Session)
Hori T, Yamamoto K, Ito T, Ikushima S, Itohara K, Kitahiro Y, Omura T, Yano I: Effect of early dose reduction of osimertinib on efficacy in the first-line treatment for EGFR-positive non-small cell lung cancer.
2023年度
原著論文
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Nishiguchi H, Omura T, Sato A, Kitahiro Y, Yamamoto K, Kunimasa J, Yano I. Luteolin protects against 6-hydoroxydopamine-induced cell death via an upregulation of HRD1 and SEL1L. Neurochem Res, 49 (1): 117-128 (2024)
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Kitahiro Y, Yamamoto K, Yakushijin K, Ioroi T, Tanda M, Itohara K, Omura T, Minami H, Yano I. The Efficacy of Bepotastine Besilate Compared With Hydroxyzine Pamoate for Preventing Infusion Reactions to the First Dose of Rituximab in Patients With Non-Hodgkin Lymphoma: Protocol for a Phase II, Double-Blind, Multicenter Randomized Trial. JMIR Res Protoc, 13: e54882 (2024)
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Sakaue T, Yamamoto K, Itohara K, Kitahiro Y, Endo T, Yokoyama N, Ishimura T, Omura T, Yano I. Population pharmacokinetics of everolimus in renal transplant recipients receiving long-term multiple immunosuppressive therapy. Drug Metab Pharmacokinet. 56: 101009 (2024)
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Tanda M, Yamamoto K, Hori T, Nishiguchi H, Yagi M, Shimizu M, Konishi T, Ozaki T, Yoshioka N, Tachihara M, Ito T, Ikushima S, Omura T, Yano I. Association of STAT3, CYP3A5, and ABCG2 Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients. Anticancer Res, 43 (4): 1775-1783 (2023)
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Mahdy WYB, Yamamoto K, Ito T, Fujiwara N, Fujioka K, Horai T, Otsuka I, Imafuku H, Omura T, Iijima K, Yano I. Physiologically-based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate. Clin Transl Sci, 16 (4): 618-630 (2023)
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Fujimoto T, Hyodo Y, Ishimura T, Tashiro Y, Endo T, Nisioka S, Yokoyama N, Yamamoto K, Yano I, Fujisawa M. Association of alpha-actinin-3 polymorphism with sarcopenia in kidney transplant recipients. Transplant Proc, 55 (4): 824-828 (2023)
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Hori T, Yamamoto K, Ito T, Ikushima S, Omura T, Yano I. Upfront Use of First-/Second-Generation EGFR-TKI Followed by Osimertinib Shows Better Prognosis than Upfront Osimertinib Therapy in Japanese Patients with Non-small-cell Lung Cancer with Exon 19 Deletion: A Single-Center Retrospective Study. Biol Pharm Bull, 46 (6): 788-795 (2023)
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Kurimura T, Yamamoto K, Tanaka H, Toba T, Kimura T, Habu Y, Itohara K, Kitahiro Y, Omura T, Yano I. Significance of pharmacist intervention to oral antithrombotic therapy in the pharmaceutical outpatient clinic of cardiovascular internal medicine: a retrospective cohort study. J Pharm Health Care Sci, 9 (1): 28 (2023)
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Nakayama Y, Enomoto D, Yamamoto K, Takara K. Molecular Characteristics of Everolimus-resistant Renal Cell Carcinoma Cells Generated by Continuous Exposure to Everolimus. Anticancer Res, 43 (10): 4349-4357 (2023)
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Tomida T, Itohara K, Yamamoto K, Kimura T, Fujita K, Uda A, Kitahiro Y, Yokoyama N, Hyodo Y, Omura T, Yano I. A model-based pharmacokinetic assessment of drug-drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19. Drug Metab Pharmacokinet, 53: 100529 (2023)